TGF-β3, but Not TGF-β1, Protects Keratinocytes against 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Deathin Vitro and in Vivo
نویسندگان
چکیده
منابع مشابه
Expression of TGF-β1 and β3 but not apoptosis factors relates to flow-induced aortic enlargement
BACKGROUND Cell proliferation and apoptosis are both involved in arterial wall remodeling. Increase in blood flow induces arterial enlargement. The molecular basis of flow-induced remodeling in large elastic arteries is largely unknown. METHODS An aortocaval fistula (ACF) model in rats was used to induce enlargement in the abdominal aorta. Aortic gene expression of transforming growth factors...
متن کاملDifferentiation of Human Leukemias in Response to 12 - O - Tetradecanoylphorbol - 13 - Acetate In Vitro
Leukemic cells from patients with acute myeloid leukemia underwent morphological. functional. and histochemical changes within 24-48 hr after treatment with 1 .6 x iO’ M 12-0-tetradecanoylphorbol-13-acetate (TPA). The changes included adhesion to the plastic substrate. a 4-6-fold increase in the number of phagocytic cells, and an increase in the number of alpha-naphthyl-acetate esterase (a-NAE)...
متن کاملDiverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung
Diverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung. R.K. Coker, G.J. Laurent, S. Shahzeidi, N.A. Hernández-Rodríguez, P. Pantelidis, R.M. du Bois, P.K. Jeffery, R.J. McAnulty. ERS Journals Ltd 1996. ABSTRACT: A role for transforming growth factor-beta1 (TGF-β1) has been proposed in lung development and in the pathogenesis of pulmonary disease. However, previous ...
متن کاملTransient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown in cell cultures to enhance the frequency of resistance to methotrexate. However, we found that TPA could also partially protect human KB cells over a short time (72 h) from the cytotoxicity of several antitumor agents, including 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene)-beta-D-glucopyranoside (VP-16), vincris...
متن کاملCell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma
LCN2 is involved in various cellular functions, including transport of small hydrophobic molecules, protection of MMP9 from proteolytic degradation, and regulating innate immunity. LCN2 is elevated in multiple human cancers, frequently being associated with tumor size, stage, and invasiveness. Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.7.4213